GENETIC MUTATIONS - EXPLAINED BY DR. SAGHIV - PART IV

WE MIGHT BE TALKING NONSENSE HERE!

Let's dedicate this post to explaining the next four types of genetic mutations in addition to those in part III of this series of posts about genetic mutations. Obviously, one post cannot include all the information relevant to every mutation, yet I will explain and indicate the main pointers regarding this next four genetic mutation types.

Nonsense genetic mutations:

This is a point mutation that results in a codon with no meaning (does not code for anything functional; a nonsense codon), or a premature stop codon (causing translation to be terminated earlier than required). The possible outcomes can be a shorter than normal protein, an incomplete protein, a dysfunctional protein, or a non-functional protein.

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Silent genetic mutations:

Silent mutations are also known as neutral mutation. These are mutations that do not have any influence on function. This usually means that the mutation did not effect the sequence of amino acids within the protein. This change typically takes place at the third position of the codon (third nucleotide of the codon) also known as the wobble position. It is called the wobble position since it has a greater chances of facilitating mutations.

Chromosome translocation genetic mutations:

This mutation is the result of the unusual arrangement of the chromosomes. These may include a change in chromosome structure and content caused by translocation; Multiple genes may be transferred between chromosomes (translocated; change their location). Such translocation mutations can cause disorders of growth, development, and function of the body's cells and systems.

Chromosomal inversion genetic mutations:

These mutations are the outcome of the abnormal flipping in direction of part of a chromosome, or the entire chromosome. This requires that the part of chromosome or the entire chromosome get detached (breaks apart in two different locations of the chromosome) and then reconnected in the opposite direction (facing backwards compared to its correct and normal direction). The possible implication of chromosomal inversion genetic mutations are numerous, extremely harmful, and possibly deadly. The reading frame of the genetic code is most likely changed dramatically.

I have included 5 more genetic mutations out of the 13 common mutation types that exist, more to follow in the next post of this series of posts dedicated to genetic mutations. Stay tuned, subscribe on the website for FREE, follow on twitter, or subscribe to my YouTube channel. KIIP by Dr. Saghiv.

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